SecReT6, T6SS database

Vibrio parahaemolyticus

Experimental investigation has been performed.

Bioinformatics investigation has been performed

T6SS ID	Type	Organism	Replicon (Accession)	Location	Function
T6SS00044	i5	Vibrio parahaemolyticus RIMD 2210633	chromosome II (NC_004605)	1074208..1108114	anti-eukaryotic; effector translocation; adherence
T6SS00043	i1	Vibrio parahaemolyticus RIMD 2210633	chromosome I (NC_004603)	1486402..1526996	anti-eukaryotic; anti-bacterial; effector translocation; adherence; virulence
T6SS00719	i1	Vibrio parahaemolyticus BB22OP	chromosome I (NC_019955)	1464178..1493343	anti-bacterial
T6SS00720	i5	Vibrio parahaemolyticus BB22OP	chromosome II (NC_019971)	1048650..1070709	anti-bacterial
T6SS01247	i1	Vibrio parahaemolyticus strain T9109	chromosome (NZ_JTGR01000038)	206703..237535	anti-bacterial
T6SS01250	i5	Vibrio parahaemolyticus strain D4	chromosome (NZ_NNJE01000049)	1..20649	anti-bacterial
T6SS01251	i1	Vibrio parahaemolyticus strain D4	chromosome (NZ_NNJE01000075)	1500..20954	anti-bacterial
T6SS01252	i5	Vibrio parahaemolyticus strain A3	chromosome (NZ_NNQJ01000119)	69..19440	anti-bacterial
T6SS01253	i5	Vibrio parahaemolyticus strain 12-009A/1335	chromosome (NZ_MYFF01000494)	7384..30649	anti-bacterial
T6SS01254	i1	Vibrio parahaemolyticus strain 12-009A/1335	chromosome (NZ_MYFF01000478)	10921..33508	anti-bacterial
T6SS01262	i1	Vibrio parahaemolyticus strain 12-297/B	chromosome (NZ_MYFG01000475)	22753..40086	anti-bacterial
T6SS01255	Unknown	Vibrio parahaemolyticus strain 12297B	chromosome (-)	-	anti-bacterial

Experimental investigation has been performed.

Bioinformatics investigation has been performed

Regulator ID	Locus tag (Gene)	Related T6SS	Regulator type	Regulatory pathway	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID	Target (Regulation)
REG0100	VP_RS12495 (barA)	T6SS00043 ; T6SS00044	protein	TCS-HK	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	2712492..2715290 (+)	491625032	Hcp expression and secretion (↓)
REG0101	VP_RS09470 (UvrY)	T6SS00043 ; T6SS00044	protein	TCS-RR	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	2037468..2038112 (-)	491529158	CsrB (↓)
REG0102	VP_RS12395 (CsrA)	T6SS00043 ; T6SS00044	protein	carbon storage regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	2688313..2688510 (-)	490550575	Hcp and vgrG expression and secretion (↓)
REG0103	CsrB1	T6SS00043 ; T6SS00044	ncRNA	carbon storage regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	2438728..2439035 (+)	-	VP_RS12395 (CsrA) (↑)
REG0104	CsrB2	T6SS00043 ; T6SS00044	ncRNA	carbon storage regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	3215766..3216162 (-)	-	VP_RS12395 (CsrA) (↑)
REG0105	CsrB3	T6SS00043 ; T6SS00044	ncRNA	carbon storage regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	plasmid (NC_004605)	171473..171785 (+)	-	VP_RS12395 (CsrA) (↑)
REG0106	vp2049 (Thymidylate kinase, Tmk)	T6SS00043	protein	Unknown	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	2150113..2150745 (-)	28898823	T6SS1 (VgrG1) expression and secretion (↓)
REG0107	VP1028 (TfoY)	T6SS00043	protein	c-di-GMP regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	1077946..1078536 (-)	28897802	T6SS1 (VgrG1) expression and secretion (↓)
REG0108	vp1391	T6SS00043	protein	Global regulator	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	1491226..1492857 (-)	28898165	T6SS1 (VgrG1) expression and secretion (↓)
REG0109	vp1407	T6SS00043	protein	Unknown	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	1511565..1512017 (-)	28898181	T6SS1 (VgrG1) expression and secretion (↓)
REG0110	VP1133 (hns)	T6SS00043	protein	Global regulator	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	1189718..1190125 (-)	28897907	VP1028 (TfoY) (↑)
REG0111	VP2762 (AphA)	T6SS00043 ; T6SS00044	protein	QS regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	2929909..2930448 (+)	28899536	T6SS1 transcript (↑); T6SS2 (VPA1027-1024, VPA1043-1028,VPA1044-1046) transcripts (↑)
REG0112	VP2516 (opaR)	T6SS00043 ; T6SS00044	protein	QS regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	2653215..2653829 (+)	28899290	vp1407 (↑); VP1388 promotor (↑); VP1400 promotor (↑); VP1409 promotor (↑); T6SS2 (Hcp2) expression and secretion (↓); VPA1027-1024 transcript (↓); VPA1027-1024 transcript (↓); VPA1027-1024 transcript (↓); VPA1043-1028 transcript (↓); VPA1044-1046 transcript (↓)
REG0114	VP0820 (ToxR)	T6SS00043	protein	Transcription regulator	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	847892..848770 (-)	28897594	VP1400 promotor (↑); VP1409 promotor (↑)
REG0115	VP0350 (CalR/LeuO)	T6SS00044	protein	Transcription regulator	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	344763..345722 (+)	28897124	VPA1027 (hcp2) promotor (↓); VPA1043 (Fha) promotor (↓); VP1133 (H-NS) (↓)
REG0116	VPA1088 (cdpA)	T6SS00043	protein	c-di-GMP regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004605)	1147728..1150091 (+)	28900943	VP1028 (TfoY) (↑)
REG0117	VPA0739 (vdcA)	T6SS00043	protein	c-di-GMP regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004605)	772439..773809 (+)	28900594	VP1028 (TfoY) (↓)
REG0118	VP2516 (OpaR)	T6SS00043	protein	Global regulator	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	2653215..2653829 (+)	28899290	T6SS1 (↓)
REG0119	VP1241 (TfoX)	T6SS00044 ; T6SS00043	protein	QS regulatory pathway; c-di-GMP regulatory pathway	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	1309223..1309810 (+)	28898016	T6SS2 (↓); T6SS1 (↓)
REG0329	VPBB_RS05425 (H-NS)	T6SS00719	protein	Transcription regulator	Vibrio parahaemolyticus BB22OP	chromosome (NC_019955)	1170475..1170882 (-)	505109423	VgrG1 expression and secretion (↑)

Experimental investigation has been performed.

Bioinformatics investigation has been performed

Effector ID	Locus tag (Gene)	Classification	Cognate immunity protein	Related T6SS	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID
EFF01832	VPBB_RS15030 (Tme1)	Tme	IMU00352	T6SS00719	Vibrio parahaemolyticus BB22OP	chromosome (NC_019955)	3247654..3248586 (+)	505110423
EFF01834	PO79_RS05910 (Tme2)	Tme	IMU00353	T6SS01247	Vibrio parahaemolyticus strain T9109	chromosome (NZ_JTGR01000043)	165330..166532 (+)	835943566
EFF01294	VP_RS06875	Tde	IMU00052	T6SS00043	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	1522167..1524323 (+)	28898189
EFF01295	VP_RS21220	Tde	-	T6SS00043	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004605)	1341875..1344451 (+)	28901118
EFF01530	V12_14465 (PoNe)	Tde	IMU00334 ; IMU00351	T6SS01262	Vibrio parahaemolyticus strain 12-297/B C4271	chromosome (NZ_MYFG01000470)	18950..20299 (-)	659039135
EFF01293	VP_RS06745	Tse	IMU00051	T6SS00043	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	1483454..1485205 (+)	28898162
EFF01533	V12_14465 (PoNe)	Tse	-	T6SS01262	Vibrio parahaemolyticus strain 12-297/B C4271	chromosome (NZ_MYFG01000470)	17970..18953 (-)	639578399
EFF01829	B5C30_RS14470 (VgrG1b)	-	-	T6SS01262	Vibrio parahaemolyticus strain 12-297/B C4271	chromosome (NZ_MYFG01000470)	20614..22692 (-)	490886759
EFF00060	VP_RS06770	-	-	T6SS00043	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	1495971..1496489 (+)	28898167
EFF00061	VP_RS20100	-	-	T6SS00044	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004605)	1081544..1082023 (-)	28900882
EFF01830	VPBB_RS06670 (VgrG1)	-	-	T6SS00719	Vibrio parahaemolyticus BB22OP	chromosome (NC_019955)	1467896..1469974 (+)	505109564
EFF01831	VPBB_RS19920 (Hcp2)	-	-	T6SS00720	Vibrio parahaemolyticus BB22OP	chromosome (NC_019971)	1050543..1051022 (-)	491518336
EFF01833	PO79_RS04645 (VgrG1)	-	-	T6SS01247	Vibrio parahaemolyticus strain T9109	chromosome (NZ_JTGR01000038)	231739..233817 (-)	491637679

Experimental investigation has been performed.

Bioinformatics investigation has been performed

Immunity protein ID	Locus tag (Gene)	Related T6SS	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Cognate effector
IMU00051	VP_RS06750	T6SS00043	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	1485278..1486405 (+)	28898163	EFF01293
IMU00052	VP_RS06880	T6SS00043	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004603)	1524323..1524916 (+)	28898190	EFF01294
IMU00275	Vti2	T6SS00043	Vibrio parahaemolyticus RIMD 2210633	chromosome (NC_004605)	-		-
IMU00353	PO79_RS05915 (Tmi2)	T6SS01247	Vibrio parahaemolyticus strain T9109	chromosome (NZ_JTGR01000043)	166529..166984 (+)	646368409	EFF01834
IMU00334	V12_14460 (PoNi)	T6SS01262	Vibrio parahaemolyticus strain 12-297/B C4271	chromosome (NZ_MYFG01000470)	17970..18953 (-)	639578399	EFF01530
IMU00351	B5C30_RS14460	T6SS01262	Vibrio parahaemolyticus strain 12-297/B C4271	chromosome (NZ_MYFG01000470)	17970..18953 (-)	639578399	EFF01530
IMU00352	VPBB_RS15035 (Tmi1)	T6SS00719	Vibrio parahaemolyticus BB22OP	chromosome (NC_019955)	3248576..3249004 (+)	491520929	EFF01832

Experimental investigation has been performed.

Bioinformatics investigation has been performed

ID	Locus tag (Gene)	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Response to T6SS attack	Known or putative function

Experimental investigation has been performed.

Bioinformatics investigation has been performed

Accessory protein ID	Locus tag (Gene)	Related T6SS	Type	Organism	Replicon (Accession)	Coordinates (Strand)	Protein GI	Related structure protein	Related effector